Selected Publications


GM Martin, C Yoshioka, EA Rex, Q Xie, J Fay, MR Whorton, JZ Chen*, SL Shyng* (2017).  "Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating."  eLife, accepted. (* Co-communication authors)  Preprint available at:

JZ Chen (2016).  "Single-Particle 3D Reconstruction beyond the Nyquist Frequency."  Submitted.

R Marabini, B Carragher, S Chen, JZ Chen, A Cheng, KH Downing, J Frank, RA Grassucci, H Bernard, W Jiang, S Jonic, HY Liao, SJ Ludtke, S Patwari, AL Piotrowski, A Quintana, CO Sorzano, H Stahlberg, J Vargas, NR Voss, W Chiu and JM Carazo (2015).  "CTF Challenge: Result Summary."  Journal of Structural Biology 190(3): 348-359.

D Barthelme*, JZ Chen*, J Grabenstatter, TA Baker and RT Sauer (2014).  "Architecture and assembly of the archaeal Cdc48*20S proteasome."  PNAS 111(17): E1687-1694. (* Co-first authors)

KR Andersen, E Onischenko, JH Tang, P Kumar, JZ Chen, A Ulrich, JT Liphardt, K Weis and TU Schwartz (2013).  "Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors."  eLife 2: e00745.

EF Vieux, ML Wohlever, JZ Chen, RT Sauer and TA Baker (2013).  "Distinct quaternary structures of the AAA+ Lon protease control substrate degradation."  PNAS 110(22): E2002-2008.

AF Brilot, JZ Chen, A Cheng, J Pan, SC Harrison, CS Potter, B Carragher, R Henderson and N Grigorieff (2012).  "Beam-induced motion of vitrified specimen on holey carbon film."  Journal of Structural Biology 177(3): 630–637.

R Henderson, S Chen, JZ Chen, N Grigorieff, LA Passmore, L Ciccarelli, JL Rubinstein, RA Crowther, PL Stewart, PB Rosenthal (2011).  "Tilt-Pair Analysis of Images from a Range of Different Specimens in Single-Particle Electron Cryomicroscopy."  Journal of Molecular Biology 413(5): 1028-1046.

EC Settembre*, JZ Chen*, PR Dormitzer, N Grigorieff and SC Harrison (2011). "Atomic model of an infectious rotavirus particle."  EMBO J. 30(2): 408-416. (* Co-first authors)

JZ Chen*, EC Settembre*, ST Aoki, X Zhang, AR Bellamy, PR Dormitzer, SC Harrison and N Grigorieff (2009). "Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM."  PNAS 106(26): 10644-10648. (* Co-first authors)

JZ Chen, C Sachse, C Xu, T Mielke, C Spahn and N Grigorieff (2008). "A Dose-Rate Effect in Single-Particle Electron Microscopy."  Journal of Structural Biology 161(1): 92-100.

C Sachse, JZ Chen, P Coureux, ME Stroupe, M Fandrich and N Grigorieff (2007).  "High-Resolution Electron Microscopy of Helical Specimens: A Fresh Look at Tobacco Mosaic Virus."  Journal of Molecular Biology 317(3): 812-835.

JZ Chen and N Grigorieff (2006). "SIGNATURE: A single-particle selection system for molecular electron microscopy." Journal of Structural Biology 157(1): 168-173.

FA Samatey, H Matsunami, K Imada, S Nagashima, TR Shaikh, DR Thomas, JZ Chen, DJ DeRosier, A Kitao and K Namba (2004). "Structure of the Bacterial Flagellar Hook and Implication for the Molecular Universal Joint Mechanism." Nature 431: 1062-1068.

JZ Chen, J Furst, MS Chapman and N Grigorieff (2003). "Low-Resolution Structure Refinement in Electron Microscopy." Journal of Structural Biology 144: 144-151.

J Furst, RB Sutton, JZ Chen, AT Brunger and N Grigorieff (2003). "Electron Cryomicroscopy Structure of N-Ethyl Maleimide Sensitive Factor at 11 Resolution." The EMBO Journal 22(17): 4365-4374.

JZ Chen, SM Pizer, EL Chaney and S Joshi (2002). "Medical Image Synthesis via Monte Carlo Simulation." Medical Image Computing and Computer Assisted Intervention 2488: 347-354.

SM Pizer, S Joshi, T Fletcher, M Styner, G Tracton and JZ Chen (2001). "Segmentation of Single-Figure Objects by Deformable M-reps." Medical Image Computing and Computer Assisted Intervention 2208: 862-869.

JZ Chen and MS Chapman (2001). "Conformational Disorder of Proteins Assessed by Real Space Molecular Dynamics Refinement." Biophysical Journal 80: 1466-1472.

JZ Chen, E Blanc and MS Chapman (1999). "Real Space Molecular Dynamics Structural Refinement." Acta Crystallographica D55: 464-468.

JZ Chen, E Blanc and MS Chapman (1999). "Improved Free R-factors for the Cross Validation of Macromolecular Structures." Acta Crystallographica D55: 219-224.